Hybridization causes outbreeding depression that worsens with genetic distance. Genetic distance alone poorly predicts hybridization success. Model shows magnitude of depression increases with larger population size. Magnitude rises with lower mutation rate. Magnitude increases with cross-fertilization. Magnitude grows with higher recombination rate. Duration of depression increases with larger population size. Duration rises with partial self-fertilization. Disruption of local adaptation causes stronger but shorter depression. Disruption of intrinsic coadaptation causes weaker but longer depression. One migrant per generation damages as much as 50:50 mixture. Translocation risks worsening genetic erosion via outbreeding depression.