Osteoblast development genes enriched for high FST SNPs between Africans, Europeans, and East Asians. Hair follicle development genes show high population differentiation driving racial hair morphology differences. Pigmentation genes have significantly higher FST consistent with skin color variation among races. Nervous system development genes like neuron differentiation enriched for high FST SNPs. Reproduction genes including spermatid development and sperm motility show elevated differentiation. Pituitary gland development genes have highest lambda value of 19.37 for high FST. Metabolic pathways like triglyceride and glucose homeostasis display high FST. Mendelian disease genes surprisingly enriched for high FST SNPs indicating population differences in incidence. Complex disease genes have excess low FST SNPs from purifying selection. Immunity genes show low differentiation due to balancing selection. MicroRNA targeted genes under strong purifying selection with low FST. Pairwise FST high across CEU-YRI, EA-YRI, CEU-EA for these gene groups. Positive selection drives differentiation beyond demographic history. Skeletal genes evolved rapidly post-agriculture with high FST. EDAR and EDA2R in hair genes under recent positive selection.