Glyphosate inhibits bacterial shikimate pathway absent in humans. Commensal bacteria possess sensitive Class I EPSPS enzymes. Opportunistic pathogens often have resistant Class II EPSPS enzymes. Glyphosate exposure increases pathogens like E. coli and S. aureus. Glyphosate reduces beneficial Lactobacillus species. Glyphosate decreases butyrate-producers like Butyricicoccus. Dysbiosis raises inflammation via IL-1β, IL-6, TNF-α. High glyphosate in North American wheat from pre-harvest desiccation. 36.6% of grain products contain glyphosate residues. Early-life glyphosate exposure alters neonatal microbiome. GBH adjuvants worsen dysbiosis beyond glyphosate alone. Roundup exposure links to anxiety and depression in mice. Dysbiosis favors celiac disease via reduced gluten-degrading Rothia. Glyphosate promotes obesity-linked microbiome shifts. Studies use unrealistically high doses ignoring dietary reality.