Yoruba, Esan, Mende, and Gambian derive 2-19% genetic ancestry from unknown archaic hominin. Archaic hominin split from human lineage 360,000-1.02 million years ago. Introgression occurred 0-124,000 years ago into West African ancestors. West Africans lack Neanderthal or Denisovan DNA unlike Eurasians. 33 loci with over 50% archaic segments in Yoruba. 37 loci with over 50% archaic segments in Mende. High-frequency archaic genes include NF1 tumor suppressor, MTFR2 mitochondrial respiration, HSD17B2 hormone regulation. KCNIP4 potassium channels and TRPS1 syndrome gene also elevated. NF1, KCNIP4, TRPS1 show positive selection in Yoruba. No elevated archaic frequency at MUC7 gene. Signals indicate complex interactions between modern humans and archaic populations. West African archaic differs from Eurasian Neanderthal-Denisovan admixture.