Çayönü Tepesi thrived 8630-6800 BC as Pre-Pottery Neolithic B settlement. Site shows transition from hunting to plant and animal domestication. Pigs possibly first domesticated at Çayönü. Sheep domesticated first among animals. Cattle managed from earliest levels reaching 20% of remains but phenotypically wild until 7000 BC. Size decrease in cattle signals domestication around 7000 BC. Emmer and einkorn wheat cultivated from earliest sub-phase. Population genetically 48% Anatolian Epipaleolithic, 33% Central Zagros Neolithic, 19% South Levant Neolithic. Çayönü part of Mesopotamia Neolithic genetic cluster. Cluster forms major ancestry in Levantine and Egyptian Bronze Age samples. Old Kingdom Egyptian male carried 24% Mesopotamia Neolithic ancestry including Çayönü type. Egyptian ancestry best fits 77.6% North African Neolithic plus 22.4% Neolithic Mesopotamia. Human sacrifice evidenced by blood analysis. Grill-plan buildings elevated floors for insulation. Stelae with human faces indicate cult worship. Developed from Göbekli Tepe tradition.