Tutankhamun's parents KV55 male and Younger Lady share 11/16 alleles proving full brother-sister relation. Yuya and Amenhotep III share 6/16 alleles indicating close blood kinship. Amenhotep III and Tiye shared alleles from Yuya suggesting cousin-level incest. Tutankhamun shared 7/16 alleles with grandfather Amenhotep III far exceeding normal 25% grandparent-grandchild rate. Tiye shared 6/16 alleles with grandson Tutankhamun confirming extreme family closeness. High consanguinity traces to possible Mutemwiya as Yuya's full sister. Amenhotep II possibly fathered both Thutmose IV and Yuya making them half or three-quarter brothers. Father-daughter incest between Amenhotep III and Sitamun could explain allele matches. Mother-son incest between Tiye and Crown Prince Thutmose is another possibility for Younger Lady's parentage. 2010 JAMA study DNA patterns demand retesting with full profiles of 14 mummies. Include autosomal, mitochondrial, and amelogenin DNA for complete relations. Age forensics on KV55, Younger Lady, KV35 boy, and KV21 mummies to resolve identities. KV55 male unlikely Akhenaten if aged 18-20 at death. Younger Lady died at 15-16 likely birthing Tutankhamun. Eighteenth Dynasty extinction linked to rampant incest interconnections.