Superarchaics diverged from other humans 2.3 million years ago. Neandersovans interbred with superarchaics shortly after expanding into Eurasia around 700 ka. Superarchaic population had effective size of 20-50 thousand. Denisovans separately interbred with superarchaics. Neanderthals and Denisovans separated 737 ka ago after ancestral bottleneck to 500 individuals. Early Neanderthal population large at 16,000 then declined to 3,400. Neandersovans endured population bottleneck. Superarchaics likely descended from earliest Eurasian Homo at Dmanisi 1.85 Ma. Model supports Neanderthal admixture from early modern human ancestors. Neandersovans largely replaced superarchaics after interbreeding. Two superarchaic subpopulations mixed separately with neandersovans and Denisovans. Earliest known hominin admixture between populations separated 1.2 million years. Superarchaics entered Eurasia before neandersovan expansion. Neanderthal genomes from Altai and Vindija show population decline. Sima de los Huesos fossils predate Neanderthal-Denisovan split at 600 ka. Results favor Neanderthal lineage interpretation of early European large-brained hominins. Three African-to-Eurasia expansions: 1.9 Ma superarchaics, 700 ka neandersovans, 50 ka moderns.
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