RAD6 drives G1-S transition and cell proliferation by upregulating cyclin D1 via H2B monoubiquitination and H3K4 trimethylation.
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RAD6 promotes G1-S transition in human cells. RAD6 boosts cell proliferation. RAD6 increases cyclin D1 mRNA and protein levels. RAD6 enhances H2B monoubiquitination at CCND1 promoter. RAD6 raises H3K4me3 at CCND1 promoter. RAD6 knockdown blocks G1-S progression. RAD6 overexpression accelerates proliferation. RAD6 regulates tumor growth in vitro. RAD6 functions in human cell cycle for first time shown. RAD6 targets cancer diagnosis and prognosis.
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